Review on potential biological activities of thiosemicarbazides

Abstract

Heterocycles have contributed to the development of society from a biological and industrial point of view as well as to improve the quality of life. During the past few decades, interest has been rapidly growing in gaining insight into the properties and transformation of these heterocycles. As a result, variety of new compounds is being added to this field every year. Among the sulfur and nitrogen containing heterocyclic compounds, thiosemicarbazides and thiosemicarbazones have potential pharmacological activities. The hydrazides addition to various isothiocyanates is one of the convenient methods of the synthesis of substituted thiosemicarbazides, which are of great interest not only in terms of a possible study of biological activity, but also as the starting compounds for the synthesis. Thiosemicarbazides is a unique class of organic compounds which is not known only for its various biological activities but also as metal-chelating and anticorrosion agents. This review is focused on the current rapid proliferation of a huge amount of biological data which led to a set of bioinformatics application and their use in the process of drug discovery. It also provides an insight of the significance of computational studies, becoming important for the support of activities reported.